LeishGEM (the Leishmania genetic modification project) will use high throughput genetic tools to understand how Leishmania parasites are such successful pathogens.
This collaborative project will have two genome-wide reverse genetics screens as a foundation, followed up with cutting edge molecular biology, cell biology and data science.
LeishGEM will determine which proteins are needed for Leishmania parasites to progress through their life cycle and survive in their hosts, which stages they’re important for and where they are found in the cell.
This approach will not just find important proteins, it will find the most important proteins. We can then start assembling this knowledge to find the most important pathways for pathogenicity.
The two genome-wide screens which are the LeishGEM foundations will also be community resources: Deletion bar-seq and Leishtag. These will transform our understanding of Leishmania molecular cell biology.
Funded by a Wellcome Trust Collaborative Award
- University of Glasgow (UK): Dr Eva Gluenz
- University of York (UK): Professor Jeremy Mottram
- Oxford Brookes University (UK): Dr Jack Sunter
- University of Oxford (UK): Dr Richard Wheeler
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