Our partnerships across the world include:

JCPiL:  UK:Brazil Joint Partnership in leishmaniasis  is a large collaborative project to investigate the basic biology of Leishmaniasis.

LeishChallenge  A project to develop an effective Leishmania major human challenge model.

LeishPathNet  lays the foundations for change in the pathology of leishmaniasis.

PREV_PKDL a project to develop a vaccine for post kala azar dermal leishmaniasis (PKDL).

VALIDATE is an international network of researchers developing vaccines against globally significant diseases caused by complex intracellular pathogens

LeishGEM (the Leishmania genetic modification project) will use high throughput genetic tools to understand how Leishmania parasites are such successful pathogens.

A Global Network for Neglected Tropical Diseases  seeking new therapeutic solutions to leishmaniasis and Chagas disease.

  • Kick off meeting, June 2019

    JCPiL: UK:Brazil Joint Partnership in Leishmaniasis


    The UK:Brazil Joint Centre Partnership in Leishmaniasis (JCPiL) is a large collaborative project between UK universities (York, Durham and Glasgow) and universities in Brazil (University of São Paulo, the Federal University of Rio de Janeiro and the Federal University of Piauí).

    Researchers within YBRI’s Immunology, Haematology and Infection theme will work together to drive this project forward, and will fund five interrelated projects and three workshops to promote research at the interface of basic and clinical science, extend existing collaborations between UK and Brazil and develop new partnerships and interdisciplinary ways of working.

    The project is funded by the Newton Fund and FAPESP, a Brazilian funding agency.

    The Team 

    • University of São Paulo (Brazil): Professor Angela Cruz (co-director), Professor Hiro Goto, Professor Luiz Tosi, Professor Dario Zamboni
    • University of York (UK): Professor Jeremy Mottram (co-director), Dr Daniel Jeffares, Professor Paul Kaye, Dr Dimitris Lagos, Dr Michael Plevin, Dr Pegine Walrad
    • Federal University of Piauí (Brazil): Professor Carlos Costa
    • Federal University of Rio de Janeiro (Brazil): Professor Ana Paula Lima
    • University of Glasgow (UK): Professor Richard McCulloch, Dr Jeziel Damasceno
    • Durham University (UK):  Professor Paul Denny

    For more information please click here

  • Clinical grading workshop for cutaneous leishmaniasis held in Colombo, Sri Lanka, March 2018

    LeishChallenge


    A project with the primary outcome to develop an effective Leishmania major human challenge model with 100% lesion clearance after treatment, with the secondary outcome being to measure immune response parameters and analysis of lesion development.

    Funded by

    The Team

    • York Biomedical Research Institute, University of York (UK):  Dr Alison Layton, Professor Charles Lacey, Dr Helen Ashwin, Mrs Liz Greensted, Professor Paul Kaye, Dr Vivak Parkash
    • The Hebrew University of Jerusalem (Israel): Professor Charles Jaffe, Professor Eli Schwartz
    • Charles University Prague (Czech Republic): Professor Jovana Sádlová, Professor Petr Volf

    For more information please click here.

  • LeishPathNet


    LeishPathNet lays the foundations for change in how research and training in the pathology of leishmaniasis is conducted, with the primary aim of adding value to the clinical samples that are generously donated by patients for research or from animals used in and demonstrating the utility of digital pathology.

    Funded by the Global Challenges Research Fund (GRCF)

    The Team

    • University of Calcutta (India): Professor Mitali Chatterjee
    • University of São Paulo (Brazil): Professor Hiro Goto
    • University of York (UK): Dr Nidhi Dey, Mrs Liz Greensted, Professor Paul Kaye, Dr Dimitris Lagos, Dr Alison Layton, Dr Paul Revill, Professor Mark Sculpher, Dr Pegine Walrad
    • University of Sri Jayewardenepura (Sri Lanka): Dr Bimalka Samanthi Seneviratne, Professor Shalindra Ranasinghe, Dr Lamkma Abhayarathna, Dr Sujai Senarathne

    For more information please click here

  • The first annual meeting, Addis Ababa, Ethiopia, April 2019

    PREV_PKDL 


    PREV_PKDL is a collaborative project funded by the European & Developing Countries Clinical Trials Partnership (EDCTP2) Programme supported by the European Union. The project is the joint effort of leading European and African experts with proven track records in research and development of products against leishmaniasis.

    Funded by the European and Developing Countries Clinical Trials Partnership (EDCTP2)

    The Team

    • European Vaccine Initiative (Germany): Dr Sophie Houard
    • University of York (UK): Professor Paul Kaye
    • Institute of Endemic Diseases (Sudan): Professor Ahmed Musa
    • Makerere University (Uganda): Professor Joseph Olobo
    • Kenya Medical Research Institute (Kenya): Dr Margaret Mbuchi,
    • University of Gondar (Ethiopia): Professor Asrat Hailu
    • London School of Hygiene & Tropical Medicine (UK): Professor Simon Croft
    • Royal College of Surgeons (Ireland): Professor David Smith
    • National Institute of Immunology (India): Professor Nirmal K Ganguly

    For more information please click here

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    VALIDATE 


    VALIDATE is an international network of researchers developing vaccines against globally significant diseases caused by complex intracellular pathogens. Our initial focus is on tuberculosis (TB), leishmaniasis, melioidosis, and leprosy, which cause substantial mortality and morbidity across the globe, particularly in low and middle-income countries (LMICs). By working together, we will advance research more quickly and effectively.

  • LeishGEM


    LeishGEM (the Leishmania genetic modification project) will use high throughput genetic tools to understand how Leishmania parasites are such successful pathogens.

    This collaborative project will have two genome-wide reverse genetics screens as a foundation, followed up with cutting edge molecular biology, cell biology and data science.

    LeishGEM will determine which proteins are needed for Leishmania parasites to progress through their life cycle and survive in their hosts, which stages they’re important for and where they are found in the cell.

    This approach will not just find important proteins, it will find the most important proteins. We can then start assembling this knowledge to find the most important pathways for pathogenicity.

    The two genome-wide screens which are the LeishGEM foundations will also be community resources: Deletion bar-seq and Leishtag. These will transform our understanding of Leishmania  molecular cell biology.

    Funded by a Wellcome Trust Collaborative Award

    The Team

    • University of Glasgow (UK): Dr Eva Gluenz
    • University of York (UK): Professor Jeremy Mottram
    • Oxford Brookes University (UK): Dr Jack Sunter
    • University of Oxford (UK): Dr Richard Wheeler

    For more information please click here

  • HUB network meeting January 2020

    A Global Network for Neglected Tropical Diseases 


    We comprise an international consortium of academic researchers from South America, Asia and the UK, seeking new therapeutic solutions to leishmaniasis and Chagas disease, and funded by UKRI’s Global Challenges Research Fund (GCRF).  We are:

    1.  Delivering a multidisciplinary, collaborative research initiative to identify new in-parasite drug targets for leishmaniasis and Chagas disease

    2.  Training Ph.D. students and early career researchers around the world with the vital and specialised skills needed for this work

    3.  Building capacity worldwide through knowledge transfer across the Network and assisting with enhancing research infrastructure at our partner institutions in developing countries

    Funded by the Global Challenges Research Fund (GRCF)

    The Team 

    • Durham University (UK): Professor Graham Sandford, Professor Paul Denny, Professor Steven L Cobb, Professor Ehmke Pohl, Dr Brian Mantilla, Dr Hachemi Kadri, Dr Kalesh Karunakaran, Professor Patrick Steel
    • University of Karachi (Pakistan): Professor M Iqbal Choudhary
    • CSIR-Indian Institute of Chemical Biology (Kolkata, India): Professor Nahid Ali
    • University of São Paulo (Brazil): Professor Ariel Silber, Professor Silvia RB Uliana
    • Federal University of Rio de Janeiro (Brazil): Professor Bartira Rossi-Bergmann, Dr Ana Paula Lima
    • University of York (UK): Dr Nathaniel Jones, Professor Jeremy Mottram, Dr Katrien van Boxclaer, Dr Pegine Walrad, Professor Anthony J Wilkinson, Professor Paul Kaye
    • Institut Pasteur de Montevideo (Uruguay): Professor Carlos Robello
    • Federal University of Minas Gerais (Brazil): Professor Santuza Teixeira
    • CSIR-Institute of Microbial Technology (Chandigarh, India): Dr Pradip Sen
    • Universidad Nacional de Rosario (Argentina): Professor Guillermo Labadie, Dr Julia Cricco
    • University of Buenos Aires (Argentina): Professor Claudio Pereira
    • State University of Campinas (Brazil): Dr Adriano Cappellazzo Coelho
    • For more information please click here